Biogenesis and function of fibrillin assemblies
نویسندگان
چکیده
منابع مشابه
Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis
The extracellular matrix (ECM) plays a key role in tissue formation, homeostasis and repair, mutations in ECM components have catastrophic consequences for organ function and therefore, for the fitness and survival of the organism. Collagen, fibrillin and elastin polymers represent the architectural scaffolds that impart specific mechanic properties to tissues and organs. Fibrillin assemblies (...
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Human vascular smooth muscle cells have been used to assess the implied role of connective tissue microfibrils as cellular ligands. Preparations of intact high-M(r) microfibrillar assemblies of collagen VI and of fibrillin, respectively, were isolated from foetal bovine skin and used as ligands in cell attachment and spreading assays. Intact collagen VI microfibrils were capable of mediating ce...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2009
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-009-0822-x